arthritis research & therapy impact factor

https://doi.org/10.3899/jrheum.181095. 2017;33(4):57183. 30085534 Bookshelf ID: NBK518992 Excerpt Arthritis is derived from the Greek term disease of the joints. It is defined as an acute or chronic joint inflammation that often co-exists with pain and structural damage. The full resultsof the study, which might be more specific about who should or should not take them, have not yet been released. Get involved in our research Its possible that stair use may be a more sensitive litmus test. Arthritis Rheum. Doctors should talk to all women of reproductive age about contraception and pregnancy-safe medications. Dr. Costenbader also looked at studies that could influence clinical care, including one focusing on whether RA patients in remission should reduce their medication. Cite this article. RMD Open. Developing a complex vocational rehabilitation intervention for CDC conducts or supports research to strengthen the public health Predetermined biopsy target sites were (i) the articular surface of the radius (proximal site), (ii) the articular surfaces of the carpal bones (distal site), and (iii) the vault of the joint capsule, especially where the synovium appeared thicker (vault site) (Fig. The FDA approved its use for lupus nephritis in October 2021. WebRheumatoid arthritis, or RA, is an autoimmune and inflammatory disease, which means that your immune system attacks healthy cells in your body by mistake, causing inflammation (painful swelling) in the affected parts of the body. At the 1-month follow-up, no patients showed infectious complications. Watch nowasKaren Costenbader, MD,tackles questions from our arthritis community about recent FDA warnings about JAK inhibitors, the effectiveness of treat-to-target strategies, tapering of DMARDs, new medications for lupus and vasculitis and addressing disparities in osteoarthritis care for under-served and minority patients. 3). Given the significance of each trajectory group, it may be useful to ask about both current and past stair use to paint a full picture of this high-demand functional test. Introduction Inflammatory arthritis (IA), (IA encompasses rheumatoid arthritis (RA), axial spondyloarthritis (axSpA), and psoriatic arthritis (PsA)) are chronic inflammatory diseases characterised by swelling of the joints, stiffness, fatigue, pain, mental distress, and reduced mobility [ 1, 2, 3, 4 ]. Article Listen now to the Live Yes! Web2021 Arthritis Research Highlights The 2021 American College of Rheumatology (ACR) Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. However, for patients who had any abnormality on objective assessments of neuropathy,did not have any statisticallysignificantassociation with having persistent pain. Research If theres one term that epitomizes the coronavirus pandemic, its probably emergency use authorization or EUA. LDS and SB conceived the work, contributed to the acquisition, analysis, and interpretation of patient data, and drafted the manuscript. The access route through the anatomical snuff box in US-guided synovial biopsies of the RC joint allows for a safe and targeted collection of adequate tissue samples. Comparing the extent and quality of the synovial inflammatory process in different areas of the same joint may also provide spatial information on specific pathogenetic mechanisms, unraveling those of district origin, which might be more closely related to complex osteitic or enthesitic processes [26]. Some estrogen-containing contraceptives are safe for women with well-controlled lupus and no antiphospholipid antibodies, but all women with lupus should avoid the estrogen patch. 2015;67(10):260110. Arthritis Rheum. The maximum tolerated number of biopsies per joint was attempted, aiming for a minimum of 12 samples (1mm diameter size at macroscopic evaluation) to be retrieved among the three target sites and through a target procedural time of 30 min [12]. They stand in the soft tissue concavity between the tendons of the extensor pollicis longus and the extensor digitorum or between the extensor pollicis longus and the extensor carpi radialis longus or between the extensor digitorum and the extensor carpi ulnaris, approximately 1cm distal to the Listers tubercle. Rheumatologists throughout the world recorded information in this database about their patients to help inform research and let others know about potential risk factors and treatments. Procedural feasibility was defined as the retrieval of histologically assessable tissue. More back pain equates with more severe disease and worse disease activity overall. They contribute $100,000 to $249,999. They contribute $250,000 to $499,999. Weve invested an incredible 4.5mn in the Centre for Epidemiology over the past decade and its had an amazing impact, touching the lives of people with arthritis right across the continent. More About Volunteering. Medical News Today Another paradox: When people with RA take drugs that lower inflammation, their LDL cholesterol goes up. It may be a combination of factors, including different genes, mechanical stress or changes in the gut microbiomethe trillions of bacteria that live in the gut and interact with the immune system. J Ultrason. PubMed https://doi.org/10.1007/s11926-011-0201-y. Since then, two other JAK inhibitors have been approved baracitinib (Olumiant) and upadacitinib (Rinvoq). In this way, whether a forceps or a semi-automatic core needle is used, the instrument penetrates the joint by less than 2cm at an angle that only reaches just part of the synovial surface, missing the synovial membrane that lines the dorsal vault of the joint capsule and the extreme medial and lateral portions of the joint. Stair use is an easy-to-capture metric for clinicians and patients are usually able to report on difficulty using the stairs much easier than if they feel like they are walking slower,addsJakiela. Researchers have also examined whether Black children with JIA have worse outcomes than their white peers. The entire procedure was generally well tolerated. WebMD Arthritis Research & Therapy They are marketed after the original drug goes off patent, increasing the number of available medications at potentially lower costs. Pain scores showed non-significant changes with a mean (SD) VAS of4 (7) immediately after biopsy, 2.3 (12) at the 1week, and3.3 (3.9) at the 1-month review (Fig. Established rheumatoid arthritis. A Representative ultrasound longitudinal scan of the radiocarpal joint. Health & Parenting Guide - Your Guide to Raising a Happy Article https://doi.org/10.1002/art.39235. In this trial, researchers used an algorithm measuring pain severity to compare results from a standard X-ray measure. Take action today - use the resources here to learn who your elected officials are, what opportunities we have to advocate from the comfort of your own home, federal and state legislation, and more! These joint symptoms may be accompanied by weight loss, fever or weakness. An interdisciplinary team of researchers from Friedrich-Alexander-Universitt Erlangen-Nrnberg (FAU) and the universities of Ulm and Wrzburg led by Prof. Falk Nimmerjahn (Chair of Genetics at FAU) has now unlocked the mechanism that causes these intravenous immunoglobulin antibodies to resolve joint inflammation in rheumatoid arthritis. Rivellese F, Surace AEA, Goldmann K, et al. Home | Arthritis.com This guide provides key facts and practical tips on women's health. However, certain comorbidities common with arthritis and related conditions, including diabetes, cardiovascular or lung disease and obesity, increased those chances significantly in some cases. Two trained operators (LDS [procedure] and SB [US assistance], with>5years of experience in US-guided biopsy) performed all biopsy procedures. Key takeaways include: Watch nowasLisa Sammaritano, MD tackles questions from our arthritis community about contraception use, planning for pregnancy, what to expect during and after pregnancy including disease activity, medication use, impact on the fetus, breastfeeding and more. Terms and Conditions, A A representative image of a patient undergoing US-guided RC synovial biopsy using a Quick-Core needle (14Gx100 mm). Correspondence to In 2021, the FDA approved three new drugs for rheumatic diseases and expanded the uses for several others. Lazarou I, Kelly SG, Meric de Bellefon L. Ultrasound-guided synovial biopsies of wrists, metacarpophalangeal, metatarsophalangeal, interphalangeal joints, and tendon sheaths. Arthritis community connects patients with others online and in-person for support and education, and encourages patients to play an active role in their health care. 1A). The greater the decreases in inflammation and disease activity, the higher the LDL and HDL (good cholesterol). The Osteoarthritis Clinical Studies Forum Series features OA thought leaders from across the globe discussing the future of how the disease can be treated to improve patient outcomes. Register as an individual or form a team and Rock the Walk in your community! https://doi.org/10.1136/rmdopen-2016-000427. Humby F, Kelly S, Bugatti S, et al. Using the National Institutes of Health-funded MultiCenter Osteoarthritis (MOST) study, participants were aged 45 to 90 with or at risk for knee OA. CM and AM conceived the work and revised the manuscript critically for important intellectual content. Lampe EW. [published Online First: 20190510]. The drug might be capable of diagnosing, preventing, or treating a particular condition (such as COVID-19), but its actual effectiveness may not be known. Theyre approved to treat certain adults and kids2years of age and older hospitalized with severe COVID symptoms. Every gift to the Arthritis Foundation will help people with arthritis across the U.S. live their best life. Arthritis is not one disease. 2019;6:2. https://doi.org/10.3389/fmed.2019.00002. Following the Medical Research Councils framework for complex interventions, WORK-ON was developed based on existing evidence, interviews with patients and rehabilitation clinicians, a workshop, HDL cholesterol, normally an anti-inflammatory particle that helps protect against the buildup of plaque in artery walls, becomes dysregulated and pro-inflammatory in active RA. Results revealed baseline variables that contribute to predicting worsening knee pain over two years include (from most to least important) depressive symptoms, walking gait speed, BMI and a series of gait variables such as bilateral coordination of gait, stride time variation, gait asymmetry, phase difference, walking pain at baseline, stride time and step length. While the two studies, one from the U.S. and one international, came to different findings, the takeaway is that the use of intravenous immunoglobulin plus glucocorticoids may have benefit, Dr. Costenbader says, although randomized control trials are needed. Discrepancies were solved by mutual agreement or by calculating the mean score (Krenns and vascularity semi-quantitative scores). In each patient, the RC joint with the highest US synovitis score was selected for biopsy. Systematic microanatomical analysis of CXCL13 and CCL21 in situ production and progressive lymphoid organization in rheumatoid synovitis. Macroscopic and histological images stained with hematoxylin and eosin (at10 magnification and detail of the lymphocyte infiltrate at20 magnification) of representative synovial tissues for each target site. Ultrasound (US)-guided synovial biopsy of the radiocarpal (RC) joint using the anatomical snuffbox as the access route. Google Scholar. Proud Partners of the Arthritis Foundation make an annual commitment to directly support the Foundations mission. Mehret Birru Talabi, MD, and Lisa Sammaritano, MD,discussed the latest American College of Rheumatology (ACR) reproductive health guidelines at the organizations 2021 Convergence conference. J Rheumatol. None had received glucocorticoid injections of the biopsied wrist in the previous 4weeks. Rheumatoid Arthritis (RA Christine Stamatos,DNP, ANP-C,tackles questions from our arthritis community about managing inflammation, sleep, mood and fibromyalgia symptoms, the role of medications and how to develop a comprehensive pain management plan. https://doi.org/10.1002/art.20444. https://doi.org/10.1002/art.10556. Think you may have arthritis? https://doi.org/10.1002/art.41184. The needle, parallel to the carpal cartilaginous floor, remained about 34mm away from it throughout its journey. Pain at the biopsy site was measured pre-biopsy (pre), immediately post-biopsy (post), after 1week (1 wk), and 1month (1 mo) using a visual analog scale (VAS) ranging from 0 to 100mm. , The tumor necrosis factor (TNF) blocker Golimumab IV (, Affects more men than women; starts at a young age, Patients much more likely to report back pain as their chief complain; about 15% to30% have inflammation in other joints, Inflammation in both sacroiliac joints (sacroiliitis)the two joints where the spine attaches to the pelvis, Symmetrical syndesmophytesbony growths in spinal ligaments that can cause the bones to fuse. [published Online First: 20210618]. Among those identified: older age, male sex, hypertension or cardiovascular disease and chronic lung disease. 16 June 2023. In September 2021, the FDA issued new warnings about the safety of the Janus kinase (JAK) inhibitors tofacitinib (Xeljanz), baricitinib (Olumiant) and upadacitinib (Rinvoq) based on new data showing a significantly increased risk of heart attack, stroke, blood clots, cancer and death. Methotrexate, leflunomide, mycophenolate and thalidomide should be stopped three months before a woman tries to get pregnant. You can find Online resource that helps patients better understand health coverage options, choose the right coverage, manage the denial process and reduce health care costs. https://doi.org/10.1016/j.hcl.2017.06.004. The pathogenic aspects. Fewer than half of patients are HLA-B27 positive; theyre more likely to have HLA-B08 or HLA-B38 genes. Certain factors specific to rheumatic conditions also were identified as risks, including the use of 10 mg or more per day of glucocorticoids, moderate to high disease activity, and immunosuppressant medications including sulfasalazine, rituximab and glucocorticoids. 2022;28(6):125668. This data shows us that post-knee replacement persistent pain is likely not due to neuropathy based on our findings of the objective assessments. Our Supporting partners are active champions who provide encouragement and assistance to the arthritis community. The anatomical snuff box is a triangular deepening that forms when the thumb is extended and abducted on the radial side of the wrist at the level of the carpal bones. Synovial tissue research: a state-of-the-art review. Rivellese F, Humby F, Bugatti S, et al. The needle could then be angled dorsally, about 20, and laterally, carpal and radial, at an angle of about 30. Learn what helps or harms the microbiome and the health of your gut and discover dietary changes that can make a difference. Histopathology. However, the radial artery crosses the snuffbox near the trapezius-scaphoid at an average distance of 7.5mm from the radial styloid, and its pulsation is easily appreciable. Data gathered included objective assessment neuropathy on exam, a PainDETECT questionnaire (PDQ) and pain severity using the WOMAC pain scale. 2019;6:102. https://doi.org/10.3389/fmed.2019.00102. Table 1, Table 2 etc.). WebScience & Research With your insights, we make sure effective arthritis treatments are 2021;21(85):e16976. https://doi.org/10.1136/rmdopen-2021-002116. The main symptoms of arthritis are joint pain and stiffness, which typically worsen with age. As of such, adults with knee OA who report decreased stair use may be prime targets for early intervention to prevent future loss of function and a potential cascade of other future poor health outcomes. BY BRYAN D. VARGO. 2004;50(8):242832. PubMed Versus Arthritis | A future free from arthritis Arthritis - Diagnosis and treatment - Mayo Clinic Nat Rev Rheumatol. Women with high levels of antiphospholipid antibodies have an increased risk of blood clots and should avoid combination estrogen-progestin birth control. In the past year, researchers also showed that: TheFDAalso issued an emergency use authorization (EUA) for combined abatacept and remdesivir (Veklury)for adults and kids2years and older hospitalized with severe COVID-19. Physicians caring for these people urgently wanted to know, too, and a Twitter chat among professionals quickly led to the establishment of a global registry. Today, the FDA says about 100 drugs are in short supply, along with vials for storing vaccines and the plastic pipettes used in newborn screening tests and basic science. Manzo A, Paoletti S, Carulli M, et al. Arthritis is a leading cause of pain and disability worldwide. Similarly, the intersection of the sensory nerve trunks with the tendons delineating the anatomical snuffbox occurs distally. The targeted disease must be life-threatening. Arthritis may impact more than just your joints. Ann Rheum Dis. Jorge Plutzky, MD, and Christina Charles-Schoeman discussed cardiovascular disease in patients withrheumatoid arthritis(RA)at the 2021 American College of Rheumatology (ACR) Convergence conference. Study uncovers gut bacteria differences in children who later If you think about the fact that we are removing the pathologic tissue contributing to the pain with the knee replacement, it has been proposed in the literature that post-surgical neuropathy is playing a role in this persistent knee pain. Arthritis Res Ther. Steinberg BD, Plancher KD, Idler RS. Help millions of people live with less pain and fund groundbreaking research to discover a cure for this devastating disease. [published Online First: 20170711]. 2007;9(5):R101. Based on the co-primary outcomes of the study, the success rate of the procedure was 95%. In summary, our results suggest that the use of the anatomical snuffbox as a gateway for performing a synovial biopsy of the RC joint in minimally invasive US-guided procedures allows not only to obtain adequate synovial tissue for histologic evaluation but may also offer a safe complementary tool for improved sampling and targeted analyses during single and serial procedures. RA mainly attacks the joints, usually many joints at once. Another trial looked at COVID-19 fatalities to try to determine risk factors. 2005;35(5):134759. Joint pain was measured pre-biopsy, immediately post-biopsy, after 1week and 1month using a visual analog scale (VAS) ranging from 0 to 100mm. WebResearch We're helping millions of people every day with breakthroughs in research. Arthritis 2019;33(5):101478. https://doi.org/10.1016/j.berh.2019.101478. After 2min, a Quick-Core biopsy needle (14Gx100 mm) was inserted into the synovial space under direct US vision. Synovitis score: discrimination between chronic low-grade and high-grade synovitis. research For foot symptom severity count, everyone-unitincrease was associated with a 7% greater hazard of all-cause mortality, with no differences by subgroup. Information for providers treating adults with arthritis. WebArthritis Action, formerly known as The Arthritic Association, has relaunched in June 2014, offering hands-on help, proven to combat arthritis pain through self-management and lifestyle. Researchers determined their neighborhood poverty score byzipcode as well as their RA function-status scores. CDC Arthritis Research. The access route through the anatomical snuffbox in ultrasound-guided synovial biopsy of the wrist allows for a safe and effective collection of tissue samples in inflammatory arthritis, https://doi.org/10.1186/s13075-023-03101-y, https://doi.org/10.1007/s11926-011-0201-y, https://doi.org/10.1016/j.berh.2019.101478, https://doi.org/10.1016/s0140-6736(20)32341-2, https://doi.org/10.1038/s41591-022-01789-0, https://doi.org/10.1136/annrheumdis-2013-204603, https://doi.org/10.1016/j.hcl.2017.06.004, https://doi.org/10.1136/annrheumdis-2021-221875, https://doi.org/10.1111/j.1365-2559.2006.02508.x, https://doi.org/10.1136/rmdopen-2016-000427, https://doi.org/10.1136/rmdopen-2021-002116, https://doi.org/10.1016/s0363-5023(05)80059-0, http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/. Many arthritis drugs are safe for men who are trying to conceive with their partner, but thalidomide and cyclophosphamide (. WebEvery woman deserves to thrive. Using data from the 2016 Survey of Childrens Health, researchers found that children who reported four or more adverse childhood events such as violence, neglect and household dysfunction were 9.4 times more likely to have arthritis than healthy kids and nearly four times more likely to have arthritis than children with other chronic physical diseases. WebThe medications used to treat arthritis vary depending on the type of arthritis. Learn about the connection between arthritis, depression and anxiety and how these conditions can make your arthritis worse. Worsening joint pain (VAS pain20) occurred in 2/20 (10%) of the patients immediately post-biopsy and in none after 1week and after 1month. See how we're aiming to address the growing shortage of arthritis specialists, especially in under-served parts of the country. arthritis This episode was originally released on January 19, 2021. In all cases, the pain was managed with analgesics and/or non-steroidal anti-inflammatory drugs. 2022;81(12):16406. Learn about the four most common warning signs. Upadacitinib was approved in recent years to treat ankylosing spondylitis (AS), and this year a trial found that tofacitinib also appears effective for AS. The study, data collection, and reporting were performed according to the EULAR points to consider for minimal reporting requirements in synovial tissue research in rheumatology [17]. Diagnostic wrist arthroscopy. [published Online First: 20200127]. Strategies aimed at preventing and treating more severe foot pain may be needed to reduce mortality. BY BRYAN D. VARGO. Joint pain as a measure of safety and tolerability of the biopsy procedure. PubMed To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Its known that there are disparities in patient self-reported pain and X-ray findings, and even greater disparity in underserved populations, Dr. Costenbader says. The answer: probably not.. The Live Yes! The mean (range) 28-Joints Disease Activity Score (DAS28) of the study population was 3.99 (2.775.07). Bruyn GA, Iagnocco A, Naredo E, et al. Kraan MC, Reece RJ, Smeets TJ, et al. Benefits of the drug must outweigh the risks. Eur J Immunol. Women with rheumatic disease can have healthy children as long as their symptoms arewell-control several months before becoming pregnant. And that the PainDETECT or PDQ may be reflective of pain severity in general, and possibly nociplastic pain, rather than neuropathic-like pain. BY BRYAN D. VARGO. We dont do a good enough job of that, the experts say. Finally, despite our proof-of-concept study allowed us to confirm a high success rate of the procedure, it is important to emphasize a limitation of the analysis that is the lack of an inter-operator variability test. Web1 - 10 of 880 Trials 2-HOBA Phase 2 Clinical Trial in Rheumatoid Arthritis This is a They contribute $500,000 to $999,000. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. The 2021 American College of Rheumatology(ACR)Convergence conferencewas recently held, gathering researchers, clinicians and patients alikefor a week ofknowledge sharing to advance treatments, understanding and approaches to managing various rheumatic diseases. 2002;46(8):20348. WebThe Arthritis Research Coalition is a registered 501 (c) (3). Liz Morasso, MSW, LCSW, OSW-C, a clinical social worker with UCLA Health who specializes in working with kids and teens tackles questions from our JA parent community about the mental health impact of COVID on kids and teens, navigating challenges of returning to school vs virtual learning, dealing with family dynamics and communication challenges about re-engaging with friends and activities and tips for productive conversations and caregiver self-care. It can be directed in the radial-ulnar direction, parallel to both the cartilaginous surface lining the carpal bones (scaphoid, lunate, and part of the pyramid bone) and the synovial lining of the upper side of the joint capsule extended between the dorsal border of the radius and the contour of the carpal condyle, until it reaches the triangular ligament of the carpus. OMERACT definitions for ultrasonographic pathologies and elementary lesions of rheumatic disorders 15 years on. Tables should be numbered and cited in the text in sequence using Arabic numerals (i.e. Therefore, we believe that carefully palpating the anatomical snuffbox and identifying the radial pulse (together with a preliminary US examination) is sufficient to delineate an actual safety zone for each patient and prevent iatrogenic vascular-nervous damage. WebParenting is one of the most complex and challenging jobs you'll face in your lifetime -- but also the most rewarding. Korcek L, Wongworawat M. Evaluation of the safe zone for percutaneous Kirschner-wire placement in the distal radius: cadaveric study. https://doi.org/10.1016/s0363-5023(05)80059-0. 1B). Clinical research on synovial tissue analysis in patients with chronic arthritis has increased in recent years. But at the same time, the FDA mandated a post-approval study for safety. Through these accesses, the needle enters the RC joint in a vertical direction or with an inclination conditioned by the extensor tendons, in any case not less than 45 in the radio-ulnar or ulnocarpal direction. Become a Volunteer Immunohistological assessment of the synovial tissue in small joints in rheumatoid arthritis: validation of a minimally invasive ultrasound-guided synovial biopsy procedure. SB reports grant/research support from Pfizer and personal fees from AbbVie, Bristol-Myers Squibb, Eli Lilly, Galapagos, Novartis and Pfizer. The aim of this study is to describe the development of WORK-ON a Cartilage covers the end of bones. Clinical research on synovial tissue analysis in patients with chronic [27] identified a small but substantial safe area of approximately 0.682 cm2 within the anatomical snuffbox near the radial styloid for percutaneous fixation of Kirschner wires. The aim of this study is to describe the development of WORK-ON a vocational rehabilitation for people with inflammatory arthritis. Those on the half dose developed an increased number of flares and disease activity. The entry of the biopsy instrument through the anatomical snuffbox offers ample guarantees against possible iatrogenic damage to joint tissues, especially cartilaginous and extra-articular. Janus kinase(JAK)inhibitors and the biologic rituximab (Rituxan) also raise risks of contacting and developing severe COVID-19. https://doi.org/10.15557/JoU.2021.0027. They contribute $2,000,000 to $2,749,000. Todetermine if avoiding stairs can lead to poor health, Jason Jakiela, MS, from the University of Delaware, studied the relationship between short-term trajectories of stair climbing frequency and incident slow gait speed over one and two years in adults with knee osteoarthritis (OA). Many shortages are related to an increased demand for critical drugs, emergency use authorizations (EUAs) that repurpose approved drugs for other uses and supply chain backups. Bugatti S, BozzallaCassione E, De Stefano L, et al. In this area, the needle can be introduced through the joint capsule. This is important because despite their shared features, some treatments that work for axPsA are surprisingly ineffective for axSpA, especially ankylosing spondylitis (AS), the more advanced form. A further 5mL of local anesthetic (1% lidocaine) was instilled into the synovial space. [published Online First: 20150601]. Every gift to the Arthritis Foundation will help people with arthritis across the U.S. live their best life. Rheumatoid arthritis is an inflammatory, autoimmune condition that can Biosimilars can be approved for pediatric use without additional clinical trials in children. There are many volunteer opportunities available. Now is the time to make your voice count, for yourself and the entire arthritis community. Here are some highlights of the latest in science and research presented at this virtual conference. WebArthritis Patient Care. Orr C, Vieira-Sousa E, Boyle DL, et al. WebArthritis Patient Care. A median number of 17 fragments (1mm diameter size at macroscopic evaluation) per procedure was processed for histopathology (range 924) and dedicated to the study.

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